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KMID : 0357920040380040213
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Korean Journal of Pathology
2004 Volume.38 No. 4 p.213 ~ p.220
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Significance of Cyclin E, p53, E-cadherin, and β-Catenin Expressions in Gastric Adenocarcinomas
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Xuan Long-Pei
Lee Mi-Ja
Suh Chae-Hong
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Abstract
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Background: Gastric cancer is reported to be one of the leading causes of mortality in Korea. Our aim was to evaluate the clinicopathologic usefulness of cyclin E, p53, E-cadherin and β-catenin expressions in gastric adenocarcinomas.
Methods: Immunohistochemical staining was performed on the 40 early gastric carcinoma (EGC) cases and 69 advanced gastric carcinoma (AGC) cases to examine the relationship with the clinicopathologic parameters.
Results: Cyclin E and p53 expressions were significantly lower in the mucosal or submucosal invasion group compared with those in the muscle invasion and subserosal or serosal invasion groups. Cyclin E expression was significantly higher in the node-positive group compared with that in the node-negative group. The loss of β-catenin expression was significantly higher in the node-negative group. p53 expression was significantly higher in the intestinal type group than that in the diffuse type group. Loss of E-cadherin expression was significantly higher in the diffuse type group. Cyclin E expression correlates with p53 expression.
Conclusions: The depth of invasion seems to correlate with cyclin E and p53 expressions. Lymph node metastasis may correlate with loss of β-catenin expression.
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KEYWORD
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Gastric cancer, Cyclin E, E-cadherin, β-catenin, p53
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